Santa Isabel is a municipality in the state o São Paulo in Brazil. The population in 2003 wis 45,516 an the aurie is 362.4 km². The elevation is 655 m.
Santa Isabel wis namit efter a Portuguese queen who wis declared a saunt bi the Roman Catholic Kirk. It wis foondit in the 18t century, as Brazil wis still a colony o Portugal. It is locatit some 50 mile east o the ceety o São Paulo, belangin tae the Guarulhos macro region, as it is pairt o the Greater São Paulo region as well.