Potosí Depairtment is a depairtment in soothwastren Bolivie. It comprises 118,218 km² wi 709,013 inhabitants (2001 census). The caipital is the ceety o Potosí. It is maistly a barren, muntainous region wi ane lairge plateau tae the wast, whaur the lairgest salt flat in the warld, Salar de Uyuni, is locatit.
It is the location o the San Cristóbal siller, zinc an lead mines an aw, developit bi the US-company Apex Silver Mines Limited o Colorado an in November 2008 sauld tae the Japanese Sumitomo Corporation.