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Frae Wikipedia, the free beuk o knawledge
Clinical data
Tred namesAdvil, Brufen, Motrin, Nurofen, etc.
Leecence data
  • AU: C
  • US: D (Evidence o risk)
Routes o
Oral, rectal, topical, an intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein bindin99%
MetabolismHepatic (CYP2C9)
Biological hauf-life1.8–2 h
CAS Nummer
PubChem CID
ECHA InfoCard100.036.152
Chemical and physical data
Molar mass206.29 g/mol
3D model (Jmol)
Density1,03 gr/ml g/cm3
Meltin pynt76 °C (169 °F)

Ibuprofen (INN) (/ˈbjuːprfɛn/ or /bjuːˈprfən/ EYE-bew-PROH-fən; from iso-butyl-propanoic-phenolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction,[1] and against swelling.

Ibuprofen has an antiplatelet effect, though relatively mild and somewhat short-lived compared with aspirin or prescription antiplatelet drugs. In general, ibuprofen has a vasodilation effect[2]. Ibuprofen is a 'core' medicine in the World Health Organization's Model List of Essential Medicines necessary that meet the minimum medical needs of a basic healthcare system.[3][4][5][6]

Ibuprofen was derived from propanoic acid by the research firm of Boots Group during the 1960s[7] and patented 1961. Orginal market as Brufen, ibuprofen is available under a variety of popular trademarks, including Motrin, Nurofen, Advil, Nuprin, and many others.[8] Generic formulations are available as well.

References[eedit | eedit soorce]

  1. Van Esch, A; Van Steensel-Moll, HA; Steyerberg, EW; Offringa, M; Habbema, JD; Derksen-Lubsen, G (Juin 1995). "Antipyretic efficacy of ibuprofen and acetaminophen in children with febrile seizures". Archives of pediatrics & adolescent medicine. 149 (6): 632–7. PMID 7767417.
  2. Apstein, CS; Vogel, WM (Januar 1982). "Coronary arterial vasodilator effect of ibuprofen". The Journal of pharmacology and experimental therapeutics. 220 (1): 167–71. PMID 7053413.
  3. WHO Model List of Essential Medicines (PDF) (16th ed.). World Health Organization (WHO). Mairch 2009. Retrieved 30 Mairch 2011.
  4. WHO Model List of Essential Medicines for Children (PDF) (2nd ed.). World Health Organization (WHO). Mairch 2010. Retrieved 30 Mairch 2011.
  5. Stuart MC; Kouimtzi M; Hill SR, eds. (2009). WHO Model Formulary 2008 (PDF) (2nd ed.). World Health Organization (WHO). ISBN 978-92-4-154765-9. Retrieved 30 Mairch 2011.
  6. WHO Model Formulary for Children 2010 (PDF) (2nd ed.). World Health Organization (WHO). 2010. ISBN 978-92-4-159932-0. Retrieved 30 Mairch 2011.
  7. Adams, SS (Apryle 1992). "The propionic acids: a personal perspective". Journal of clinical pharmacology. 32 (4): 317–23. PMID 1569234.
  8. "PubMed Health - Ibuprofen". U.S. National Library of Medicine. 1 October 2010. Retrieved 20 Januar 2011.

External links[eedit | eedit soorce]