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Clinical data
Tred names Advil, Brufen, Motrin, Nurofen, etc.
AHFS/Drugs.com monograph
MedlinePlus a682159
Leecence data
  • AU: C
  • US: D (Evidence o risk)
Routes o
Oral, rectal, topical, an intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 49–73%
Protein bindin 99%
Metabolism Hepatic (CYP2C9)
Biological hauf-life 1.8–2 h
Excretion Renal
CAS Nummer
PubChem CID
ECHA InfoCard 100.036.152
Chemical and physical data
Formula C13H18O2
Molar mass 206.29 g/mol
3D model (Jmol)
Density 1,03 gr/ml g/cm3
Meltin pynt 76 °C (169 °F)

Ibuprofen (INN) (/ˈbjuːprfɛn/ or /bjuːˈprfən/ EYE-bew-PROH-fən; from iso-butyl-propanoic-phenolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) uised for pain relief, fever reduction,[1] and against swelling.

Ibuprofen has an antiplatelet effect, tho relatively mild an somewhat short-lived compared wi aspirin or prescription antiplatelet drugs. In general, ibuprofen and has a vasodilation effect[2]. Ibuprofen is a 'core' medicine in the World Health Organization's Model List of Essential Medicines necessary that meet the minimum medical needs o a basic healthcare system.[3][4][5][6]

Ibuprofen was derived from propanoic acid by the research firm of Boots Group during the 1960s[7] and patented 1961. Orginal market as Brufen, ibuprofen is available under a variety o popular trademarks, including Motrin, Nurofen, Advil, Nuprin, and many others.[8] Generic formulations are available as well.

References[eedit | eedit soorce]

  1. Van Esch, A; Van Steensel-Moll, HA; Steyerberg, EW; Offringa, M; Habbema, JD; Derksen-Lubsen, G (June 1995). "Antipyretic efficacy of ibuprofen and acetaminophen in children with febrile seizures". Archives of pediatrics & adolescent medicine. 149 (6): 632–7. PMID 7767417. 
  2. Apstein, CS; Vogel, WM (January 1982). "Coronary arterial vasodilator effect of ibuprofen". The Journal of pharmacology and experimental therapeutics. 220 (1): 167–71. PMID 7053413. 
  3. WHO Model List of Essential Medicines (PDF) (16th ed.). World Health Organization (WHO). March 2009. Retrieved 2011-03-30. 
  4. WHO Model List of Essential Medicines for Children (PDF) (2nd ed.). World Health Organization (WHO). March 2010. Retrieved 2011-03-30. 
  5. Stuart MC; Kouimtzi M; Hill SR, eds. (2009). WHO Model Formulary 2008 (PDF) (2nd ed.). World Health Organization (WHO). ISBN 978-92-4-154765-9. Retrieved 2011-03-30. 
  6. WHO Model Formulary for Children 2010 (PDF) (2nd ed.). World Health Organization (WHO). 2010. ISBN 978-92-4-159932-0. Retrieved 2011-03-30. 
  7. Adams, SS (April 1992). "The propionic acids: a personal perspective". Journal of clinical pharmacology. 32 (4): 317–23. PMID 1569234. 
  8. "PubMed Health - Ibuprofen". U.S. National Library of Medicine. 2010-10-01. Retrieved 2011-01-20. 

External links[eedit | eedit soorce]