File:Serpin mechanism.png

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English: Serine proteases operate by a two-step catalytic mechanism. First, the substrate (blue) is attacked by the catalytic triad (red) to form an acyl-enzyme intermediate. The intermediate is typically resolved by hydrolysis by water. However, when the reactive centre loop (RCL) of a serpin is attacked, the conformational change (blue arrow) pulls the catalytic triad out of position, preventing it from completing catalysis. (Based on PDB: 1K9O, 1EZX​)
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Soorce Ain wirk
Author Thomas Shafee

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Date/TimeThummnailDimensionsUiserComment
current09:56, 22 December 2015Thumbnail fer version aes o 09:56, 22 December 20151,800 × 1,488 (513 KB)Evolution and evolvabilityHigher resolution
05:19, 19 December 2015Thumbnail fer version aes o 05:19, 19 December 20151,362 × 1,126 (300 KB)Evolution and evolvabilityMinor arrow correction
05:08, 19 December 2015Thumbnail fer version aes o 05:08, 19 December 20151,362 × 1,126 (300 KB)Evolution and evolvabilityadded arrow and removed transparency
05:04, 19 December 2015Thumbnail fer version aes o 05:04, 19 December 20151,362 × 1,114 (360 KB)Evolution and evolvabilityCross-wiki upload from en.wikipedia.org

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