Frae Wikipedia, the free beuk o knawledge
Jump to navigation Jump to search
Arginine vasopressin3d.png
AliasesAVP, ADH, ARVP, AVP-NPII, AVRP, VP, arginine vasopressin, Vasopressin
External IDsOMIM: 192340 MGI: 88121 HomoloGene: 417 GeneCards: AVP
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for AVP
Genomic location for AVP
Band20p13Start3,082,556 bp[1]
End3,084,724 bp[1]
RNA expression pattern
PBB GE AVP 207848 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 20: 3.08 – 3.08 MbChr 2: 130.58 – 130.58 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Vasopressin, an aa kent as antidiuretic hormone (ADH), is a neurohypophysial hormone foond in maist mammals. In maist species it conteens arginine an is thus an aa cried arginine vasopressin (AVP) or argipressin.[5] Its two primary functions are to retain water in the body and to constrict blood vessels.[6] Vasopressin regulates the bouk's retention o watter bi actin tae increase watter reabsorption in the kidney's collectin ducts, the tubules which receive the very dilute urine produced bi the functional unit o the kidney, the nephrons.[7][8] Vasopressin is a peptide hormone that increases watter permeability o the kidney's collectin duct an distal convolutit tubule bi inducin translocation o aquaporin-CD watter channels in the plasma membrane o collectin duct cells.[9] It an aa increases peripheral vascular resistance, which in turn increases arterial bluid pressur. It plays a key role in homeostasis, bi the regulation o water, glucose, an sauts in the bluid. It is derived frae a preprohormone precursor that is seenthesised in the hypothalamus an stored in vesicles at the posterior pituitary. Maist o it is stored in the posterior pituitary tae be released into the bluidstream. Houever, some AVP mey an aa be released directly intae the brain, an accumulatin evidence suggests it plays an important role in social behaviour, sexual motivation an pair bondin, an maternal responses tae stress.[10] It haes a very short hauf-life atween 16–24 minutes.[8]

References[eedit | eedit soorce]

  1. 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000101200 - Ensembl, May 2017
  2. 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000037727 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier.
  6. Marieb, Elaine (2014). Anatomy & physiology. Glenview, IL: Pearson Education, Inc. ISBN 978-0321861580.
  7. Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications" (PDF). In Lajtha A, Lim R (eds.). Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (3rd ed.). Berlin: Springer. pp. 573–607. ISBN 0-387-30348-0.
  8. 8.0 8.1 Babar SM (October 2013). "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy. 47 (10): 1359–63. doi:10.1177/1060028013502457. PMID 24259701.
  9. Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA (February 1995). "Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane". Proceedings of the National Academy of Sciences of the United States of America. 92 (4): 1013–7. doi:10.1073/pnas.92.4.1013. PMC 42627. PMID 7532304.
  10. Insel TR (March 2010). "The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior". Neuron (in English). 65 (6): 768–79. doi:10.1016/j.neuron.2010.03.005. PMC 2847497. PMID 20346754.CS1 maint: unrecognised leid (link)