Vasopressin

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Vasopressin
Arginine vasopressin3d.png
Identifiers
Aliases AVP
External IDs OMIM: 192340 MGI: 88121 HomoloGene: 417 GeneCards: 551
RNA expression pattern
PBB GE AVP 207848 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000490

NM_009732

RefSeq (protein)

NP_000481

NP_033862

PubMed sairch [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Vasopressin, an aa kent as antidiuretic hormone (ADH), is a neurohypophysial hormone foond in maist mammals. In maist species it conteens arginine an is thus an aa cried arginine vasopressin (AVP) or argipressin.[3] Its two primary functions are to retain water in the body and to constrict blood vessels.[4] Vasopressin regulates the bouk's retention o watter bi actin tae increase watter reabsorption in the kidney's collectin ducts, the tubules which receive the very dilute urine produced bi the functional unit o the kidney, the nephrons.[5][6] Vasopressin is a peptide hormone that increases watter permeability o the kidney's collectin duct an distal convolutit tubule bi inducin translocation o aquaporin-CD watter channels in the plasma membrane o collectin duct cells.[7] It an aa increases peripheral vascular resistance, which in turn increases arterial bluid pressur. It plays a key role in homeostasis, bi the regulation o water, glucose, an sauts in the bluid. It is derived frae a preprohormone precursor that is seenthesised in the hypothalamus an stored in vesicles at the posterior pituitary. Maist o it is stored in the posterior pituitary tae be released into the bluidstream. Houever, some AVP mey an aa be released directly intae the brain, an accumulatin evidence suggests it plays an important role in social behaviour, sexual motivation an pair bondin, an maternal responses tae stress.[8] It haes a very short hauf-life atween 16–24 minutes.[6]

References[eedit | eedit soorce]

  1. "Human PubMed Reference:". 
  2. "Mouse PubMed Reference:". 
  3. Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier. 
  4. Marieb, Elaine (2014). Anatomy & physiology. Glenview, IL: Pearson Education, Inc. ISBN 978-0321861580. 
  5. Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications" (PDF). In Lajtha A, Lim R. Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (3rd ed.). Berlin: Springer. pp. 573–607. ISBN 0-387-30348-0. 
  6. 6.0 6.1 Babar SM (October 2013). "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy. 47 (10): 1359–63. doi:10.1177/1060028013502457. PMID 24259701. 
  7. Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA (Februar 1995). "Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane". Proceedings of the National Academy of Sciences of the United States of America. 92 (4): 1013–7. doi:10.1073/pnas.92.4.1013. PMC 42627Freely accessible. PMID 7532304. 
  8. Insel TR (Mairch 2010). "The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior". Neuron (in English). 65 (6): 768–79. doi:10.1016/j.neuron.2010.03.005. PMC 2847497Freely accessible. PMID 20346754.