Sildenafil

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Sildenafil
Sildenafil structure.svg
Sildenafil-from-xtal-3D-balls.png
Clinical data
Tred namesViagra, Revatio, ithers
AHFS/Drugs.commonograph
MedlinePlusa699015
Leecence data
Pregnancy
category
  • AU: B1
  • US: B (Na risk in non-human studies)
Routes o
admeenistration
Bi mooth (tablets), IV
ATC code
Legal status
Legal status
  • AU: S4 (Prescription anly)
  • CA: Rx-anerly
  • UK: POM (Prescription anly)
  • US: Rx-anerly
  • Rx-anerly
Pharmacokinetic data
Bioavailability41% (mean)[1]
Protein bindin~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN-desmethylsildenafil (~50% potency for PDE5)
Biological hauf-life3–4 oors
ExcretionFaeces (~80%), urine (~13%)[2]
Identifiers
CAS Nummer
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
ECHA InfoCard100.122.676
Chemical and physical data
FormulaC22H30N6O4S
Molar mass474.5764 g/mol
3D model (Jmol)
 NYesY (whit is this?)  (verify)

Sildenafil, sauld as the brand name Viagra amang ithers, is a medication uised tae treat erectile dysfunction an pulmonary arterial hypertension.[3] Its effectiveness for treatin sexual dysfunction in weemen haes nae been demonstratit.[3]

References[eedit | eedit soorce]

  1. Nichols, DJ; Muirhead, GJ; Harness, JA (6 March 2002). "Pharmacokinetics of Sildenafil after Single Oral Doses in Healthy Male Subjects: Absolute Bioavailability, Food Effects and Dose Proportionality". British Journal of Clinical Pharmacology. 53: 5S–12S. doi:10.1046/j.0306-5251.2001.00027.x. PMC 1874258. PMID 11879254.
  2. "Viagra (sildenafil citrate) Tablets, for Oral Use. Full Prescribing Information". Pfizer Labs. Division of Pfizer, Inc., NY, NY 10017. Retrieved 5 November 2016.
  3. 3.0 3.1 "Sildenafil Citrate". The American Society of Health-System Pharmacists. Retrieved 1 December 2014.