Serotonin

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Serotonin
Skeletal formula o serotonin
Baw-an-stick model o the serotonin molecule
Space-fillin model o the serotonin molecule
Names
IUPAC names
5-Hydroxytryptamine or
3-(2-aminoethyl)-1H-indol-5-ol
Ither names
5-Hydroxytryptamine, 5-HT, Enteramine; Thrombocytin, 3-(β-Aminoethyl)-5-hydroxyindole, Thrombotonin
Identifiers
50-67-9 YesY
ChEBI CHEBI:28790 YesY
ChEMBL ChEMBL39 YesY
ChemSpider 5013 YesY
IUPHAR ligand
Jmol-3D images Image
KEGG C00780 YesY
MeSH Serotonin
PubChem
UNII 333DO1RDJY YesY
Properties
C10H12N2O
Molar mass 176.215 g/mol
Appearance White pouder
Meltin pynt 121–122 °C (ligroin) [1]
Boilin pynt 416 ± 30 °C (at 760 Torr) [2]
slichtly soluble
Acidity (pKa) 10.16 in watter at 23.5 °C [3]
Dipole moment 2.98 D
Hazards
Safety data sheet External MSDS
Lethal dose or concentration (LD, LC):
750 mg/kg (subcutaneous, rat),[4] 4500 mg/kg (intraperitoneal, rat),[5] 60 mg/kg (oral, rat)
Except whaur otherwise notit, data are gien for materials in thair staundart state (at 25 °C [77 °F], 100 kPa).
 YesY verify (whit isYesY/N?)
Infobox references

Serotonin /ˌsɛrəˈtnɨn/ or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Biochemically derived frae tryptophan, serotonin is primarily foond in the gastrointestinal (GI) tract, platelets, an the central nervous seestem (CNS) o animals, includin humans.

References[eedit | eedit soorce]

  1. Pietra, S.;Farmaco, Edizione Scientifica 1958, Vol. 13, pp. 75–9.
  2. Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994–2011 ACD/Labs)
  3. Mazák, K.; Dóczy, V.; Kökösi, J.; Noszál, B. (2009). "Proton Speciation and Microspeciation of Serotonin and 5-Hydroxytryptophan". Chemistry & Biodiversity 6 (4): 578–90. doi:10.1002/cbdv.200800087. PMID 19353542. 
  4. Erspamer, Vittorio (1952). Ricerca Scientifica 22: 694–702.  Missin or empty |title= (help)
  5. Tammisto, Tapani (1968). Annales Medicinae Experimentalis et Biologiea Fenniae 46 (3, Pt. 2): 382–4.  Missin or empty |title= (help)