Prolactin

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PRL
PRL structure.png
Available structurs
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRL, GHA1, prolactin
External IDsMGI: 97762 HomoloGene: 732 GeneCards: PRL
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PRL
Genomic location for PRL
Band6p22.3Start22,287,244 bp[1]
End22,297,501 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000948
NM_001163558

NM_001163530
NM_011164

RefSeq (protein)

NP_000939
NP_001157030

NP_001157002
NP_035294

Location (UCSC)Chr 6: 22.29 – 22.3 MbChr 13: 27.06 – 27.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prolactin (PRL), an aa kent as luteotropic hormone or luteotropin, is a protein that in humans is best kent for its role in enablin mammals, uisually females, tae produce milk. It is influential ower 300 separate processes in various vertebrates.[5] Prolactin is secretit frae the pituitary gland in response tae eatin, matein, estrogen treatment, ovulation an nursin. Prolactin is secretit in pulses in atween thir events. Prolactin plays an essential role in metabolism, regulation o the immune seestem an pancreatic development.

References[eedit | eedit soorce]

  1. 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000172179 - Ensembl, May 2017
  2. 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000021342 - Ensembl, May 2017
  3. "Human PubMed Reference:". 
  4. "Mouse PubMed Reference:". 
  5. Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA (Jun 1998). "Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice". Endocrine Reviews. 19 (3): 225–68. doi:10.1210/er.19.3.225. PMID 9626554.