Progesterone

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Progesterone
Progesteron.svg
Progesterone molecule
Clinical data
Tred names Utrogestan, Prometrium, Endometrin, Crinone
AHFS/Drugs.com monograph
MedlinePlus a604017
Pregnancy
category
Routes o
admeenistration
Oral, transdermal, vaginal, rectal, intramuscular or subcutaneous injection, implant
ATC code
Pharmacokinetic data
Bioavailability 10–15% (oral)[1]
Protein bindin 96%–99%
Metabolism Hepatic (CYP2C19, CYP3A4, CYP2C9)[2][3]
Biological hauf-life 16–18 oors (oral)[4]
Excretion Renal
Identifiers
Synonyms 4-pregnene-3,20-dione
CAS Nummer
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.000.318
Chemical and physical data
Formula C21H30O2
Molar mass 314.46 g/mol
3D model (Jmol)
Specific rotation [α]D
Meltin pynt 126 °C (259 °F)
 NYesY (whit is this?)  (verify)

Progesterone (abbreviatit as P4), an aa kent as pregn-4-ene-3,20-dione,[5][6] is an endogenous steroid an progestogen sex hormone involved in the menstrual cycle, pregnancy, an embryogenesis o humans an ither species.[7]

References[eedit | eedit soorce]

  1. Nagrath Arun; Malhotra Narendra; Seth Shikha (15 December 2012). Progress in Obstetrics and Gynecology--3. Jaypee Brothers Medical Publishers Pvt. Ltd. pp. 370–. ISBN 978-93-5090-575-3. 
  2. Yamazaki H, Shimada T (October 1997). "Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes". Arch. Biochem. Biophys. 346 (1): 161–9. doi:10.1006/abbi.1997.0302. PMID 9328296. 
  3. Gerard A. McKay; Matthew R. Walters (6 February 2013). Lecture Notes: Clinical Pharmacology and Therapeutics. John Wiley & Sons. p. 33. ISBN 978-1-118-34489-7. 
  4. Zutshi (1 January 2005). Hormones in Obstetrics and Gynaecology. Jaypee Brothers Publishers. p. 74. ISBN 978-81-8061-427-9. 
  5. Norman Adler; Donald Pfaff; Robert W. Goy (6 Dec 2012). Handbook of Behavioral Neurobiology Volume 7 Reproduction (1st ed.). New York: Plenum Press. p. 189. ISBN 978-1-4684-4834-4. Retrieved 4 July 2015. 
  6. "progesterone (CHEBI:17026)". ChEBI. European Molecular Biology Laboratory-EBI. Retrieved 4 July 2015. 
  7. Tekoa L. King; Mary C. Brucker (25 October 2010). Pharmacology for Women's Health. Jones & Bartlett Publishers. pp. 372–373. ISBN 978-1-4496-5800-7.