Oxytocin

Oxytocin
Clinical data
Tred names	Pitocin
AHFS/Drugs.com	monograph
Pregnancy; category	AU: A ; ;
Routes o; admeenistration	Intranasal, IV, IM
ATC code	H01BB02 (WHO) ;
Legal status
Legal status	UK: POM (Prescription anly) ; US: ℞-anly ;
Pharmacokinetic data
Protein bindin	30%
Metabolism	liver an ither oxytocinases
Biological hauf-life	1–6 min (IV); ~2 h (intranasal)
Excretion	Biliary and kidney
Identifiers
	IUPAC name 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzoyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide;
CAS Nummer	50-56-6 ;
PubChem CID	439302;
IUPHAR/BPS	2174;
DrugBank	DB00107 ;
ChemSpider	388434 ;
UNII	1JQS135EYN;
KEGG	D00089 ;
ChEBI	CHEBI:7872 ;
ChEMBL	CHEMBL395429 ;
ECHA InfoCard	100.000.045
Chemical and physical data
Formula	C43H66N12O12S2
Molar mass	1007.19 g/mol
3D model (Jmol)	Interactive eemage;
	SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O;
	InChI InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1 ; Key:XNOPRXBHLZRZKH-DSZYJQQASA-N ;
(verify)

Oxytocin (Oxt) is a hormone, neuropeptide, an medication.^[3]^[4] As a medication, it is uised tae cause contraction o the uterus in order tae stairt labour or increase the speed o labor, an tae stap bleedin follaein delivery.^[3] For this purpose, it is gien either bi injection intae a muscle or intae a vein.^[3]

References[eedit | eedit soorce]

↑ Weisman O, Zagoory-Sharon O, Feldman R (September 2012). "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582–6. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536.
↑ Huffmeijer R, Alink LR, Tops M, Grewen KM, Light KC, Bakermans-Kranenburg MJ, Ijzendoorn MH (2012). "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinology Letters. 33 (1): 21–5. PMID 22467107.
↑ ^3.0 ^3.1 ^3.2 "Oxytocin". The American Society of Health-System Pharmacists. Retrieved June 2015. Check date values in: |accessdate= (help)
↑ The Oxford Handbook of Prosocial Behavior. Oxford University Press. 2015. p. 354. ISBN 9780195399813.

[pmid22436536-1] Weisman O, Zagoory-Sharon O, Feldman R (September 2012). "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582–6. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536.

[pmid22467107-2] Huffmeijer R, Alink LR, Tops M, Grewen KM, Light KC, Bakermans-Kranenburg MJ, Ijzendoorn MH (2012). "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinology Letters. 33 (1): 21–5. PMID 22467107.

[AHFS2015-3] 3.0 ^3.1 ^3.2 "Oxytocin". The American Society of Health-System Pharmacists. Retrieved June 2015. Check date values in: |accessdate= (help)

[4] The Oxford Handbook of Prosocial Behavior. Oxford University Press. 2015. p. 354. ISBN 9780195399813.

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Oxytocin

References[eedit | eedit soorce]

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