Nicotine

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Nicotine
Nicotine.svg
Nicotine3Dan2.gif
Clinical data
Tred names Nicorette, Nicotrol
AHFS/Drugs.com monograph
Pregnancy
category
  • AU: D
  • US: D (Evidence o risk)
Dependence
liability
High
Routes o
admeenistration
Inhalation; Insufflation; Oral – Buccal, Sublingual, an Ingestion; Transdermal; Rectal,
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 20 to 45% (oral), 53% (intranasal), 68% (transdermal)
Protein bindin <5%
Metabolism Hepatic
Biological hauf-life 1-2 oors; 20 oors active metabolite (cotinine)
Excretion Urine (10-20% (gum), pH-dependent; 30% (inhaled); 10-30% (intranasal))
Identifiers
CAS Nummer
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
ECHA InfoCard 100.000.177
Chemical and physical data
Formula C10H14N2
Molar mass 162.23 g/mol
3D model (Jmol)
Density 1.01 g/cm3
Meltin pynt −79 °C (−110 °F)
Bylin pynt 247 °C (477 °F)
  (verify)

Nicotine is a potent parasympathomimetic alkaloid foond in the nichtshade faimily o plants (Solanaceae) an a stimulant drug.