Morphine

Frae Wikipedia
Jump to navigation Jump to search
Morphine
Morphin - Morphine.svg
Morphine-from-xtal-3D-balls.png
Clinical data
Tred namesMScontin, Oramorph, Sevredol, an ithers[1]
AHFS/Drugs.commonograph
Pregnancy
category
  • AU: C
  • US: C (Risk nae ruled oot)
Dependence
liability
Pheesical: Heich
Psychological: Moderate
Addiction
liability
High
Routes o
admeenistration
Inhalation (smeukin), insufflation (snortin), bi mooth (PO), rectal, subcutaneous (SC), intramuscular (IM), intravenous (IV), epidural, an intrathecal (IT)
Drog clessopiate
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability20% tae 40% (oral), 36% tae 71% (rectally),[2] 100% (IV/IM)
Protein bindin30% tae 40%
MetabolismHepatic 90%
Onset o action5 min (IV), 15 min (IM),[3] 20 min (PO)[4]
Biological hauf-life2 h tae 3 h
Duration o action3 h tae 7 h[5][6]
ExcretionRenal 90%, biliary 10%
Identifiers
CAS Nummer
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.000.291
Chemical and physical data
FormulaC17H19NO3
Molar mass285.34 g/mol
3D model (Jmol)
Solubility in watterHCl & sulf.: 60 mg/mL (20 °C)
  (verify)

Morphine is a pyne medication o the opiate teep which is foond naiturally in a nummer o plants an ainimals.[5][7] It acts directly on the central nervish seestem (CNS) tae decrease the feelin o pyne.

References[eedit | eedit soorce]

  1. drugs.com Drugs.com international listings for Morphine Page accessed 2 Juin 2015
  2. Jonsson T, Christensen CB, Jordening H, Frølund C (April 1988). "The bioavailability of rectally administered morphine". Pharmacol. Toxicol. 62 (4): 203–5. doi:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374. 
  3. Whimster, Fiona (1997). Cambridge textbook of accident and emergency medicine. Cambridge: Cambridge University Press. p. 191. ISBN 978-0-521-43379-2. 
  4. Liben, Stephen (2012). Oxford textbook of palliative care for children (2 ed.). Oxford: Oxford University Press. p. 240. ISBN 978-0-19-959510-5. 
  5. 5.0 5.1 "Morphine sulfate". The American Society of Health-System Pharmacists. Retrieved 1 June 2015. 
  6. Rockwood, Charles A. (2009). Rockwood and Wilkins' fractures in children (7th ed.). Philadelphia, Pa.: Lippincott Williams & Wilkins. p. 54. ISBN 978-1-58255-784-7. 
  7. Stefano GB, Ptáček R, Kuželová H, Kream RM (2012). "Endogenous morphine: up-to-date review 2011" (PDF). Folia Biol. (Praha). 58 (2): 49–56. PMID 22578954. Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla.