Morphine

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Morphine
Morphin - Morphine.svg
Morphine-from-xtal-3D-balls.png
Clinical data
Tred names MScontin, Oramorph, Sevredol, an ithers[1]
AHFS/Drugs.com monograph
Pregnancy
category
  • AU: C
  • US: C (Risk nae ruled oot)
Dependence
liability
Pheesical: Heich
Psychological: Moderate
Addiction
liability
High
Routes o
admeenistration
Inhalation (smeukin), insufflation (snortin), bi mooth (PO), rectal, subcutaneous (SC), intramuscular (IM), intravenous (IV), epidural, an intrathecal (IT)
Drog cless opiate
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 20% tae 40% (oral), 36% tae 71% (rectally),[2] 100% (IV/IM)
Protein bindin 30% tae 40%
Metabolism Hepatic 90%
Onset o action 5 min (IV), 15 min (IM),[3] 20 min (PO)[4]
Biological hauf-life 2 h tae 3 h
Duration o action 3 h tae 7 h[5][6]
Excretion Renal 90%, biliary 10%
Identifiers
CAS Nummer
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.000.291
Chemical and physical data
Formula C17H19NO3
Molar mass 285.34 g/mol
3D model (Jmol)
Solubility in watter HCl & sulf.: 60 mg/mL (20 °C)
  (verify)

Morphine is a pyne medication o the opiate teep which is foond naiturally in a nummer o plants an ainimals.[5][7] It acts directly on the central nervish seestem (CNS) tae decrease the feelin o pyne.

References[eedit | eedit soorce]

  1. drugs.com Drugs.com international listings for Morphine Page accessed 2 Juin 2015
  2. Jonsson T, Christensen CB, Jordening H, Frølund C (Aprile 1988). "The bioavailability of rectally administered morphine". Pharmacol. Toxicol. 62 (4): 203–5. doi:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374. 
  3. Whimster, Fiona (1997). Cambridge textbook of accident and emergency medicine. Cambridge: Cambridge University Press. p. 191. ISBN 978-0-521-43379-2. 
  4. Liben, Stephen (2012). Oxford textbook of palliative care for children (2 ed.). Oxford: Oxford University Press. p. 240. ISBN 978-0-19-959510-5. 
  5. 5.0 5.1 "Morphine sulfate". The American Society of Health-System Pharmacists. Retrieved 1 Juin 2015. 
  6. Rockwood, Charles A. (2009). Rockwood and Wilkins' fractures in children (7th ed.). Philadelphia, Pa.: Lippincott Williams & Wilkins. p. 54. ISBN 978-1-58255-784-7. 
  7. Stefano GB, Ptáček R, Kuželová H, Kream RM (2012). "Endogenous morphine: up-to-date review 2011" (PDF). Folia Biol. (Praha). 58 (2): 49–56. PMID 22578954. Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla.