Melatonin

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Nae tae be confused wi Melanin.
Melatonin
Melatonin.png
Melatonin-3d-CPK.png
Clinical data
AHFS/Drugs.com Consumer Drug Information
Routes o
admeenistration
Oral, sublingual, transdermal
ATC code
Legal status
Legal status
  • AU: S4 (Prescription anly)
  • UK: POM (Prescription anly)
  • US: OTC
Pharmacokinetic data
Bioavailability 30–50%
Metabolism Hepatic via CYP1A2 mediatit 6-hydroxylation
Biological hauf-life 35–50 minutes
Excretion Renal
Identifiers
CAS Nummer
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.000.725
Chemical and physical data
Formula C13H16N2O2
Molar mass 232.278 g/mol
3D model (Jmol)
  (verify)

Melatonin (Listeni/ˌmɛləˈtnɪn/), chemically N-acetyl-5-methoxy tryptamine,[1] is a hormone foond in animals, plants, fungi an bacteria in anticipation o the daily onset o darkness.[2] It is synthesized in ainimal cells directly frae the amino acid tryptophan, but in ither organisms through the Shikimic acid pathway.[3][4]

References[eedit | eedit soorce]

  1. "Melatonin". Sleepdex. Retrieved 17 August 2011. 
  2. Hardeland, Rüdiger; Pandi-Perumal, S.R.; Cardinali, Daniel P. (2006). "Melatonin". The International Journal of Biochemistry & Cell Biology. 38 (3): 313–316. doi:10.1016/j.biocel.2005.08.020. PMID 16219483. 
  3. Tan, Dun-Xian; Zheng, Xiaodong; Kong, Jin; Manchester, Lucien; Hardeland, Ruediger; Kim, Seok; Xu, Xiaoying; Reiter, Russel (9 September 2014). "Fundamental Issues Related to the Origin of Melatonin and Melatonin Isomers during Evolution: Relation to Their Biological Functions". International Journal of Molecular Sciences. 15 (9): 15858–15890. doi:10.3390/ijms150915858. PMC 4200856Freely accessible. PMID 25207599. 
  4. Acuna-Castroviejo, D; Escames, G; Tapias, V; Rivas, I (2006). "Melatonin, mitochondria and neuroprotection". In Montilla, Pedro; Túnez, Isaac. Melatonin: Present and Future. New York, US: Nova Science Publishers. pp. 1–33. ISBN 9781600213748.