gamma-Aminobutyric acid

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gamma-Aminobutyric acid
Simplified structural formula
GABA molecule
Names
IUPAC name
4-aminobutanoic acid
Identifiers
Jmol-3D images Image
ChEBI CHEBI:16865 N
ChEMBL ChEMBL96 YesY
ChemSpider 116 YesY
DrugBank DB02530 YesY
ECHA InfoCard 100.000.235
EC Nummer 200-258-6
KEGG D00058 YesY
MeSH gamma-Aminobutyric+Acid
RTECS nummer ES6300000
UNII 2ACZ6IPC6I YesY
Properties
C4H9NO2
Molar mass 103.120 g/mol
Appearance white microcrystalline powder
Density 1.11 g/mL
Meltin pynt 203.7 °C (398.7 °F; 476.8 K)
Bylin pynt 247.9 °C (478.2 °F; 521.0 K)
130 g/100 mL
log P −3.17
Acidity (pKa) 4.23 (carboxyl), 10.43 (amino)[1]
Hazards
Main hazards Irritant, Hairmfu
Lethal dose or concentration (LD, LC):
12,680 mg/kg (moose, oral)
Except whaur itherwise notit, data are gien for materials in thair staundart state (at 25 °C [77 °F], 100 kPa).
YesY verify (whit is YesYN ?)
Infobox references

γ-Aminobutyric acid (/ˈɡæmə əˈmnbjuːˈtɪrk ˈæsd/; or GABA /ˈɡæbə/) is the chief inhibitory neurotransmitter in the mammalian central nervous seestem. It plays the principal role in reducin neuronal excitability throuoot the nervous seestem. In humans, GABA is an aa directly responsible for the regulation o muscle tone.[2]

References[eedit | eedit soorce]

  1. Dawson RMC, Elliot DC, Elliot WH, Jones KM, ed. (1959). Data for Biochemical Research. Oxford: Clarendon Press.  [page needit]
  2. Watanabe M, Maemura K, Kanbara K, Tamayama T, Hayasaki H (2002). "GABA and GABA receptors in the central nervous system and other organs". In Jeon KW. Int. Rev. Cytol. International Review of Cytology. 213. pp. 1–47. ISBN 978-0-12-364617-0. PMID 11837891. doi:10.1016/S0074-7696(02)13011-7.