Diazepam

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Diazepam
Diazepam structure.svg
Diazepam ball-and-stick model.png
Clinical data
Tred namesValium, Vazepam, Valtoco, ithers[4]
AHFS/Drugs.commonograph
MedlinePlusa682047
Leecence data
Pregnancy
category
  • AU: C
  • US: D (Evidence o risk)
Dependence
liability
Moderate
Addiction
liability
Moderate[1][2]
Routes o
admeenistration
By mouth, IM, IV, rectal, nasal spray[3]
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability76% (64–97%) bi mooth, 81% (62–98%) rectal[5]
MetabolismLiverCYP2B6 (minor route) tae desmethyldiazepam, CYP2C19 (major route) tae inactive metabolites, CYP3A4 (major route) tae desmethyldiazepam
Biological hauf-life(50 oors); 20–100 oors (36–200 oors for main active metabolite desmethyldiazepam)
ExcretionNeer
Identifiers
CAS Nummer
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.006.476
Chemical and physical data
FormulaC16H13ClN2O
Molar mass284.74 g·mol−1
3D model (Jmol)
 NYesY (whit is this?)  (verify)

Diazepam, first mercated as Valium, is a medicine o the benzodiazepine faimily that teepically produces a caumin effect.[6] It is commonly uised tae treat a range o condeetions, includin anxeeity, seizurs, alcohol widrawal syndrome, benzodiazepine widrawal syndrome, muscle spasms, tribble sleepin, an restless legs syndrome.[6]

References[eedit | eedit soorce]

  1. Clinical Addiction Psychiatry. Cambridge University Press. 2010. p. 156. ISBN 9781139491693. Archived frae the oreeginal on 2017-09-08.
  2. Ries, Richard K. (2009). Principles of addiction medicine (4 ed.). Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. p. 106. ISBN 9780781774772. Archived frae the oreeginal on 2017-09-08.
  3. "Valtoco- diazepam spray". DailyMed. 13 January 2020. Retrieved 13 February 2020.
  4. 4.0 4.1 "National Highway Traffic Safety Administration Drugs and Human Performance Fact Sheet- Diazepam". Archived frae the oreeginal on 2017-03-27. Retrieved 2017-11-13.
  5. Dhillon S, Oxley J, Richens A (March 1982). "Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients". British Journal of Clinical Pharmacology. 13 (3): 427–32. doi:10.1111/j.1365-2125.1982.tb01397.x. PMC 1402110. PMID 7059446.
  6. 6.0 6.1 Calcaterra NE, Barrow JC (April 2014). "Classics in chemical neuroscience: diazepam (valium)". ACS Chemical Neuroscience. 5 (4): 253–60. doi:10.1021/cn5000056. PMC 3990949. PMID 24552479.