Codeine

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Codeine
Skeletal formula
Space-fillin model
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a682065
Pregnancy
category
  • AU: A
  • US: C (Risk nae ruled oot)
Dependence
liability
Heich
Routes o
admeenistration
bi mooth, rectal, SC, IM
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability Bo mopth: ~90%
Metabolism Liver: CYP2D6 (tae morphine), CYP3A4 (tae norcodeine), UGT2B7 (tae 3- an 6-glucuronides o codeine, norcodeine, an morphine)[1]
Onset o action 15–30 minutes[2]
Biological hauf-life 2.5–3 hours
Duration o action 4–6 hours[2]
Identifiers
Synonyms 3-Methylmorphine
CAS Nummer
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.000.882
Chemical and physical data
Formula C18H21NO3
Molar mass 299.364 g/mol
3D model (Jmol)
 NYesY (whit is this?)  (verify)

Codeine is an opiate uised tae treat pyne, as a coch medicine, an for diarrhea.[2][3]

References[eedit | eedit soorce]

  1. Shen H, He MM, Liu H, et al. (August 2007). "Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17". Drug Metab. Dispos. 35 (8): 1292–300. doi:10.1124/dmd.107.015354. PMID 17470523. 
  2. 2.0 2.1 2.2 "Codeine". The American Society of Health-System Pharmacists. Retrieved January 5, 2016. 
  3. Prommer, E (2010). "Role of codeine in palliative care". Journal of opioid management. 7 (5): 401–6. PMID 22165039.