Aspirin

Frae Wikipedia
Lowp tae: navigation, rake
Aspirin
Systematic (IUPAC) name
2-acetoxybenzoic acid
Cleenical data
AHFS/Drugs.com monograph
MedlinePlus a682878
Pregnancy cat. C (AU) D (US)
Legal status Unscheduled (AU) GSL (UK) OTC (US)
Routes Maist commonly oral, an aa rectal, lysine acetylsalicylate mey be given IV or IM
Pharmacokinetic data
Bioavailability Rapidly an completely absorbed
Protein bindin 99.6%
Metabolism Hepatic
Hauf-life 300–650 mg dose: 3.1–3.2 h
1 g dose: 5 h
2 g dose: 9 h
Excretion Renal
Identifiers
CAS nummer 50-78-2 YesY
ATC code A01AD05 B01AC06, N02BA01
PubChem CID 2244
DrugBank DB00945
ChemSpider 2157 YesY
UNII R16CO5Y76E YesY
KEGG D00109 YesY
ChEBI CHEBI:15365 YesY
ChEMBL CHEMBL25 YesY
Synonyms 2-acetyloxybenzoic acid
acetylsalicylate
acetylsalicylic acid
O-acetylsalicylic acid
Chemical data
Formula C9H8O4 
Mol. mass 180.157 g/mol
Pheesical data
Density 1.40 g/cm³
Melt. pynt 136 °C (277 °F)
Boilin pynt 140 °C (284 °F) (decomposes)
Solubility in watter 3 mg/mL (20 °C)
 YesY (what is this?)  (verify)

Aspirin (USAN), an aa kent as acetylsalicylic acid (/əˌsɛtəlˌsælɨˈsɪlɨk/ ə-SET-əl-SAL-i-SIL-ik; abbreviatit ASA), is a salicylate drug, eften uised as an analgesic tae relieve minor aches an pains, as an antipyretic tae reduce fever, an as an anti-inflammatory medication. Aspirin wis first isolatit bi Felix Hoffmann, a chemist wi the German company Bayer in 1897.[1][2]

Salicylic acid, the main metabolite o aspirin, is an integral pairt o human an ainimal metabolism. While in humans much o it is attributable tae diet, a substantial pairt is synthesized endogenously.[3]

Aspirin an aa haes an antiplatelet effect bi inhibitin the production o thromboxane, which unner normal circumstances binds platelet molecules thegither tae create a patch ower damaged walls o bluid vessels. Acause the platelet patch can acome too lairge an an aa block bluid flow, locally an dounstream, aspirin is an aa uised lang-term, at law doses, tae help prevent heart attacks, strokes, an bluid clot formation in fowk at heich risk o developin bluid clots.[4] It haes an aa been established that law doses o aspirin mey be given immediately efter a heart attack tae reduce the risk o anither heart attack or o the daith o cardiac tissue.[5][6] Aspirin mey be effective at preventin certain types o cancer, particularly colorectal cancer.[7][7][8][9]

The main undesirable side effects o aspirin taken bi muith are gastrointestinal ulcers, stomach bleedin, an tinnitus, especially in heicher doses. In childer an adolescents, aspirin is na langer indicatit tae control flu-like symptoms or the symptoms o chickenpox or ither viral illnesses, acause o the risk o Reye's syndrome.[10]

Aspirin is pairt o a group o medications cried nonsteroidal anti-inflammatory drugs (NSAIDs), but differs frae maist ither NSAIDs in the mechanism o action. Tho it, an ithers in its group cried the salicylates, hae similar effects (antipyretic, anti-inflammatory, analgesic) tae the ither NSAIDs an inhibit the same enzyme cyclooxygenase, aspirin (but nae the ither salicylates) daes so in an irreversible manner an, unlike ithers, affects mair the COX-1 variant than the COX-2 variant o the enzyme.[11]

The day, aspirin is ane o the maist widely uised medications in the warld, wi an estimatit 40,000 tonnes o it bein consumed each year.[12] In kintras whaur Aspirin is a registered trademark awned bi Bayer, the generic term is acetylsalicylic acid (ASA).[13]

References[eedit | eedit soorce]

  1. PMID 11124191 (PubMed)
    Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
  2. Karsten Schrör (2009). Acetylsalicylic acid. ISBN 978-3-527-32109-4. 
  3. PMID 19053387 (PubMed)
    Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
  4. Lewis, H D; J W Davis, D G Archibald, W E Steinke, T C Smitherman, J E Doherty, H W Schnaper, M M LeWinter, E Linares, J M Pouget, S C Sabharwal, E Chesler, H DeMots (18 August 1983). "Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study". The New England Journal of Medicine 309 (7): 396–403. doi:10.1056/NEJM198308183090703. ISSN 0028-4793. PMID 6135989. 
  5. Julian, D G; D A Chamberlain, S J Pocock (24 September 1996). "A comparison of aspirin and anticoagulation following thrombolysis for myocardial infarction (the AFTER study): a multicentre unblinded randomised clinical trial". BMJ (British Medical Journal) 313 (7070): 1429–1431. doi:10.1136/bmj.313.7070.1429. PMC 2353012. PMID 8973228. 
  6. Krumholz, Harlan M.; Martha J. Radford, Edward F. Ellerbeck, John Hennen, Thomas P. Meehan, Marcia Petrillo, Yun Wang, Timothy F. Kresowik, Stephen F. Jencks (1995). "Aspirin in the Treatment of Acute Myocardial Infarction in Elderly Medicare Beneficiaries : Patterns of Use and Outcomes". Circulation 92 (10): 2841–2847. doi:10.1161/01.CIR.92.10.2841. PMID 7586250. 
  7. 7.0 7.1 Algra, Annemijn M; Rothwell, Peter M (2012). "Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials". The Lancet Oncology 13 (5): 518–27. doi:10.1016/S1470-2045(12)70112-2. PMID 22440112. 
  8. Rothwell, Peter M; Price, Jacqueline F; Fowkes, F Gerald R; Zanchetti, Alberto; Roncaglioni, Maria Carla; Tognoni, Gianni; Lee, Robert; Belch, Jill FF et al. (2012). "Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials". The Lancet 379 (9826): 1602. doi:10.1016/S0140-6736(11)61720-0. 
  9. Rothwell, Peter M; Wilson, Michelle; Price, Jacqueline F; Belch, Jill FF; Meade, Tom W; Mehta, Ziyah (2012). "Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials". The Lancet 379 (9826): 1591. doi:10.1016/S0140-6736(12)60209-8. 
  10. Macdonald S (2002). "Aspirin use to be banned in under 16-year olds". BMJ 325 (7371): 988. doi:10.1136/bmj.325.7371.988/c. PMC 1169585. PMID 12411346. 
  11. Burke, Anne; Smyth, Emer; FitzGerald, Garret A. (2006). "26: Analgesic Antipyretic and Antiinflammatory Agents". Goodman and Gilman's the pharmacological basis of therapeutics (11 ed.). New York: McGraw-Hill. pp. 671–716. ISBN 978-0-07-142280-2. 
  12. Warner, T. D.; Warner TD, Mitchell JA (2002). "Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?". Proc Natl Acad Sci USA 99 (21): 13371–3. doi:10.1073/pnas.222543099. PMC 129677. PMID 12374850. 
  13. "The use of aspirin". Wordconstructions.com. Retrieved 11 May 2011. 

Freemit airtins[eedit | eedit soorce]